Comparative Genomics Research Group

Research Topics

¢£Pair-wise and multiple alignment of protein and genomic sequences
¢£Fast genome mapping and spliced alignment of transcripts for discovery and structural prediction of eukaryotic genes
¢£Analysis of function, structure, sequence, and evolution (FESS) relationships of cytochrome P450 gene superfamily



¢£click for full size(325KB)

Team Member

Osamu Gotoh
Invited Senior Research Scientist E-mail
Osamu Gotoh
Key Words

sequence analysis, sequence alignment, gene finding, comparative genomics, gene evolution, cytochrome P450


Mariko Morita
AIST
Research Staff
E-mail
Key Words

gene finding, drug metabolism, cytochrome P450


Papers List

  • ¢£Gotoh, O. (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267, pp.83-90.
  • ¢£Gotoh, O. (1996) Significant improvement in accuracy of multiple protein sequence alignments by iterative refinement as assessed by reference to structural alignments. J. Mol. Biol. 264, pp.823-838.
  • ¢£Nakato, R. and Gotoh, O. (2010) Cgaln: fast and space-efficient whole-genome alignment. BMC Bioinformatics, 11, 224.
  • ¢£Ichinose, N., Yada, T., Gotoh, O. (2012) A large-scale motif discovery using a DNA Gray code and equiprobable oligomers, Bioinformatics, 28, pp.25-31.
  • ¢£Iwata, H. and Gotoh, O. (2012) Benchmarking spliced alignment programs including an extended version of spaln (spaln2) that incorporates additional species-specific features, Nucleic Acid Res., in press.
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